Frontiers in Discovery and Care: Genetics and Genomic Sciences 2025

Frontiers in Discovery and Care: Genetics and Genomic Sciences 2025

Cutting-edge research and clinical innovations from Mount Sinai’s Department of Genetics and Genomic Sciences

The Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai advances biomedical discovery and translates it into clinical impact—bringing together genomic science, computational approaches, and patient-centered research to improve diagnosis, prevention, and treatment.

Across these stories, you’ll see how our teams move from mechanism to medicine: leveraging resources such as Mount Sinai’s diverse BioMe biobank and a clinical research engine that has supported 50+ clinical trials, including first-in-human studies and emerging therapeutic approaches.

In this report: neurogenomics, rare disease trials, AI-enabled precision medicine, immunogenomics and interception strategies, microbiome-driven discovery, and new approaches to diagnosis and therapy for rare and metabolic disorders.