What follows showcases the extraordinary breadth and depth of research conducted by the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, highlighting our department's leadership in translating genetic discoveries into clinical solutions.
Our department has established itself as a global leader in genetics research, driven by an unwavering commitment to improving human health through innovative science. As one of the nation's most highly NIH-funded genetics departments, we have built a robust research ecosystem that spans from fundamental genetic discoveries to clinical applications that directly benefit patients.
These pages highlight nine research programs that exemplify our department's impact: uncovering the microglia-mediated mechanisms underlying Alzheimer's disease; revolutionizing rare disease clinical trials through novel therapeutic approaches; harnessing artificial intelligence to power precision medicine for diverse populations; pioneering disease interception strategies for Crohn's disease; integrating genomics and microbiome research for therapeutic discovery; providing diagnostic answers for families affected by rare genetic disorders; advancing precision therapies for metabolic disorders; and developing individualized care approaches through innovative technologies.
Each featured research program demonstrates our department's core strengths: cutting-edge scientific methodology, clinical translation capabilities, and collaborative approaches to complex medical challenges. From Dr. Alison Goate's pioneering work on Alzheimer's disease genetics to the innovative clinical trials led by Dr. Manisha Balwani, our faculty are reshaping the landscape of genetic medicine.
The work highlighted here reflects our department's commitment to serving patients who need us most—those with rare diseases, complex genetic disorders, and conditions that have historically been difficult to diagnose or treat. Through our dedicated Clinical Trials Office, state-of-the-art research facilities, and partnerships with leading institutions worldwide, we are transforming the promise of precision medicine into reality.
These stories serve as a testament to the exceptional work being conducted by our faculty, staff, and trainees, and highlight the significant impact our research has on advancing human health and improving patient outcomes globally.