Eric J. Nestler, MD, PhD
While researchers increasingly understand the body as a single irreducible system, Mount Sinai continues to serve a patient population representing the world—that larger system of which we are all a part. Side by side, our scientists and clinicians work to illuminate the relationship of the two and to advance new knowledge and therapeutics for the benefit of humanity.
At Mount Sinai, researchers often walk down the hall to learn about one another’s projects, discovering unexpected opportunities for partnership or for thinking outside of the box. The close proximity of researchers and clinicians makes the translation of discoveries into treatments—and an emphasis on patient-centered research—core to our institution.
Strengthened by our interdependence, we are poised to become one of the nation’s first true learning health systems, which you will read more about in this report, and which will accelerate the advancements we are making in the fields of science and medicine across the globe. This goal involves learning from each other and from our expansive patient population, continuing the tradition of collaborative and bold discovery that defines Mount Sinai.
As we reflect on 2025 and look forward to 2026 and beyond, I hope you come away knowing this is the place you want to be—to think and create with the brightest minds, to advance your work and career, supported by opportunities for professional development, and to transform health care in our community and around the world.
Eric J. Nestler, MD, PhD
Anne and Joel Ehrenkranz Dean,
Icahn School of Medicine at Mount Sinai
Executive Vice President
Chief Scientific Officer
Mount Sinai Health System