Sakura—The Elaborate Branches and Spines of a Cerebellar Purkinje Neuron Call to Mind a Springtime Cherry Tree in Bloom

Sakura—The Elaborate Branches and Spines of a Cerebellar Purkinje Neuron Call to Mind a Springtime Cherry Tree in Bloom

THIS INVERTED AND pseudo-colored confocal image was obtained from an adult mouse Purkinje neuron iontophoretically filled with Lucifer Yellow fluorescent dye.

Credit: Mary (Molly) Heyer, PhD, Instructor, Paul Kenny Lab, Nash Family Department of Neuroscience

Dr. Heyer studies the roles of small RNAs in regulating Purkinje neuron function and downstream behaviors. Cerebellar abnormalities, such as altered Purkinje neuron activity, have been strongly linked to disorders, for example, autism and schizophrenia. The Drug Discovery Institute, which serves as a hub for the development of new drugs that result from basic and clinical research programs across the Mount Sinai Health System, is pursuing novel ways to modulate Purkinje neuron activity, which may lead to new strategies for treating these disorders.